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Page 1
Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion.
Leone RD, Zhao L, Englert JM, Sun IM, Oh MH, Sun IH, Arwood ML, Bettencourt IA, Patel CH, Wen J, Tam A, Blosser RL, Prchalova E, Alt J, Rais R, Slusher BS, Powell JD. Leone RD, et al. Among authors: arwood ml. Science. 2019 Nov 22;366(6468):1013-1021. doi: 10.1126/science.aav2588. Epub 2019 Nov 7. Science. 2019. PMID: 31699883 Free PMC article.
Discovery of DRP-104, a tumor-targeted metabolic inhibitor prodrug.
Rais R, Lemberg KM, Tenora L, Arwood ML, Pal A, Alt J, Wu Y, Lam J, Aguilar JMH, Zhao L, Peters DE, Tallon C, Pandey R, Thomas AG, Dash RP, Seiwert T, Majer P, Leone RD, Powell JD, Slusher BS. Rais R, et al. Among authors: arwood ml. Sci Adv. 2022 Nov 18;8(46):eabq5925. doi: 10.1126/sciadv.abq5925. Epub 2022 Nov 16. Sci Adv. 2022. PMID: 36383674 Free PMC article.
Targeting glutamine metabolism enhances tumor-specific immunity by modulating suppressive myeloid cells.
Oh MH, Sun IH, Zhao L, Leone RD, Sun IM, Xu W, Collins SL, Tam AJ, Blosser RL, Patel CH, Englert JM, Arwood ML, Wen J, Chan-Li Y, Tenora L, Majer P, Rais R, Slusher BS, Horton MR, Powell JD. Oh MH, et al. Among authors: arwood ml. J Clin Invest. 2020 Jul 1;130(7):3865-3884. doi: 10.1172/JCI131859. J Clin Invest. 2020. PMID: 32324593 Free PMC article.
New scaffolds for type II JAK2 inhibitors overcome the acquired G993A resistance mutation.
Arwood ML, Liu Y, Harkins SK, Weinstock DM, Yang L, Stevenson KE, Plana OD, Dong J, Cirka H, Jones KL, Virtanen AT, Gupta DG, Ceas A, Lawney B, Yoda A, Leahy C, Hao M, He Z, Choi HG, Wang Y, Silvennoinen O, Hubbard SR, Zhang T, Gray NS, Li LS. Arwood ML, et al. Cell Chem Biol. 2023 Jun 15;30(6):618-631.e12. doi: 10.1016/j.chembiol.2023.05.007. Epub 2023 Jun 7. Cell Chem Biol. 2023. PMID: 37290440
mTORC1 Promotes T-bet Phosphorylation To Regulate Th1 Differentiation.
Chornoguz O, Hagan RS, Haile A, Arwood ML, Gamper CJ, Banerjee A, Powell JD. Chornoguz O, et al. Among authors: arwood ml. J Immunol. 2017 May 15;198(10):3939-3948. doi: 10.4049/jimmunol.1601078. Epub 2017 Apr 19. J Immunol. 2017. PMID: 28424242 Free PMC article.